If you’ve ever tried Retin-A (or one of its many cousins: Renova, Avita, Tazorac, generic tretinoin, etc.), you know the usage downsides: redness, flaking, stinging. Some MDs will tell you to just push through the irritation period (and walk around with a flushed, flakey face for months)—or to wait thirty minutes after you cleanse to apply. However, I don’t know about you, but by the time I get around to washing my face at night, I'm beat. No way I’m delaying bed for another half hour.