A reader recently emailed and asked me if there was an advantage to starting Botox at 40 before she had any lines etched—or if it made sense (and was more cost effective) to wait and do it once she noticed lines didn’t disappear anymore when her face was at rest. I started Botox at 33 so you already know where I fall on this issue, but I did ask Gary Goldenberg, MD, Assistant Clinical Professor of Dermatology at The Mount Sinai School of Medicine in New York City, for his opinion.